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KMID : 0378019680110080073
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New Medical Journal
1968 Volume.11 No. 8 p.73 ~ p.78
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The Effect of Histamine, Serotonin, Nor-epinephrine, Epinephrine, Acetylcholine, and Formalin Administration on the Serum Haptoglobin Level in Rabbit
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Abstract
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Serum haptoglobin is a fraction in the alpha2 globulin which is characterized by its combining property with free hemoglobin. It was partially cleared by Jayle et al .2) to be a glycoprotein and latter it was demonstrated by Smithies3) that there are several genetic types by starch gel electrophoresis. These genetic types of haptoglobin have been intensively studied recently with special references to human biochemical genetics and anthropological view point 427) However. the exact physiological function of the haptoglobin is not clearly understood as yet. It is well known that serum haptoglobin level changes in various pathological conditions, for instance, its concentration increases in acute infection, reumatic affections, nephrosis, and carcinomatosis, and, on the contrary, it decreases in liver cirrhosis, hepatitis, and hemolytic anemia. In addition, serum haptoglobin level could be elevated experimentally in rabbit or guinea pig by adminstration of terpentine6i,61) or some proteolytic enzytic enzymes (papain, elestase etc) .63) However, the exact mechanism of such artificially induced hyperhaptoglobinemia is still unkown.
The present work was undertaken to elucidate such mechanism and investigated the effect of histamine, serotonin, nor-epinephrine, epinephrine, acetylcholine and formalin adminstration on the serum haptoglobin level in rabbit. All the above described amine derivatives elevated serum haptoglobin level in rabbit, but very slightly compared to the terpentine adminstration. Acetylcholine had no effect on the serum haptoglobin level. On the other hand, subcutaneous adminstration of 10 ml of 4 per cent formalin induced remarkable hyperhaptoglobinemia comparable to the terpentine adminstration. The degree of hyperhaptoglobinemia produced by formalin was not related with the dosage and the number of adminstration.
From these observations it was concluded that the. effect of formalin or terpentine on the serum haptoglobin level is not a direct one but an indirect action, and that such effect was not mediated through the action of histamine, serotonin, nor-epinephrine, epinephrine or acetylcholine.
The possible role of adrenocortical hormone on the haptoglobin mobilization from the haptoglobin pool has been discussed.
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KEYWORD
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